Protein kinase C-dependent control of Bcl-x alternative splicing.


The alternative splicing of Bcl-x generates the proapoptotic Bcl-x(S) protein and the antiapoptotic isoform Bcl-x(L). Bcl-x splicing is coupled to signal transduction, since ceramide, hormones, and growth factors alter the ratio of the Bcl-x isoforms in different cell lines. Here we report that the protein kinase C (PKC) inhibitor and apoptotic inducer… (More)


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@article{Revil2007ProteinKC, title={Protein kinase C-dependent control of Bcl-x alternative splicing.}, author={Timoth{\'e}e Revil and Johanne Toutant and Lulzim Shkreta and Daniel Garneau and Philippe Cloutier and Benoit Chabot}, journal={Molecular and cellular biology}, year={2007}, volume={27 24}, pages={8431-41} }