Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.

@article{Park2007ProteinKC,
  title={Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.},
  author={Jin-Ah Park and Anne L. Crews and W. Randall Lampe and Shijing Fang and Joungjoa Park and Kenneth B. Adler},
  journal={The American journal of pathology},
  year={2007},
  volume={171 6},
  pages={1822-30}
}
Mucin hypersecretion is a major pathological feature of many respiratory diseases, yet cellular mechanisms regulating secretion of mucin have not been fully elucidated. Previously, we reported that mucin hypersecretion induced by human neutrophil elastase involves activation of protein kinase C (PKC), specifically the delta-isoform (PKC delta). Here, we further investigated the role of PKC delta in mucin hypersecretion using both primary human bronchial epithelial cells and the human bronchial… CONTINUE READING