Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo

@inproceedings{Chen2013ProteinKC,
  title={Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo},
  author={Zhihong Chen and Lora W. Forman and Robert M. Williams and Douglas V Faller},
  booktitle={BMC Cancer},
  year={2013}
}
A subpopulation of tumor cells with distinct stem-like properties (cancer stem-like cells, CSCs) may be responsible for tumor initiation, invasive growth, and possibly dissemination to distant organ sites. CSCs exhibit a spectrum of biological, biochemical, and molecular features that are consistent with a stem-like phenotype, including growth as non-adherent spheres (clonogenic potential), ability to form a new tumor in xenograft assays, unlimited self-renewal, and the capacity for… CONTINUE READING
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The proliferation and survival of human neuroendocrine tumors is dependent upon protein kinase C-delta

  • Z Chen, LW Forman, KA Miller, B English, A Takashima, RA Bohacek
  • Endocr Relat Cancer
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Highly Influential
12 Excerpts

The proliferation and survival of human neuroendocrine tumors is dependent upon protein kinase C-delta

  • Z Chen, LW Forman, KA Miller, B English, A Takashima, RA Bohacek
  • Endocr Relat Cancer
  • 2011
Highly Influential
12 Excerpts