Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.

@article{House1987ProteinKC,
  title={Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.},
  author={Colin House and Bruce E. Kemp},
  journal={Science},
  year={1987},
  volume={238 4834},
  pages={1726-8}
}
The regulatory domain of protein kinase C contains an amino acid sequence between residues 19 and 36 that resembles a substrate phosphorylation site in its distribution of basic residue recognition determinants. The corresponding synthetic peptide (Arg19-Phe-Ala-Arg-Lys-Gly-Ala25-Leu-Arg-Gln-Lys-Asn-Val-His -Glu-Val-Lys-Asn36) acts as a potent substrate antagonist with an inhibitory constant of 147 +/- 9 nM. It is a specific inhibitor of protein kinase C and inhibits both autophosphorylation… CONTINUE READING
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