Protein kinase C betaII plays an essential role in dendritic cell differentiation and autoregulates its own expression.

@article{Cejas2005ProteinKC,
  title={Protein kinase C betaII plays an essential role in dendritic cell differentiation and autoregulates its own expression.},
  author={Pedro J. Cejas and Louise M. Carlson and Jian Zhang and Swami Padmanabhan and Despina Kolonias and Inna Lindner and Stephen M. Haley and Lawrence H. Boise and Kelvin P Lee},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 31},
  pages={28412-23}
}
Dendritic cells (DC) arise from a diverse group of hematopoietic progenitors and have marked phenotypic and functional heterogeneity. The signal transduction pathways that regulate the ability of progenitors to undergo DC differentiation, as well as the specific characteristics of the resulting DC, are only beginning to be characterized. We have found previously that activation of protein kinase C (PKC) by cytokines or phorbol esters drives normal human CD34(+) hematopoietic progenitors and… CONTINUE READING
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