Protein kinase C and phospholipase D: intimate interactions in intracellular signaling

  title={Protein kinase C and phospholipase D: intimate interactions in intracellular signaling},
  author={Kevin P Becker and Yusuf A. Hannun},
  journal={Cellular and Molecular Life Sciences CMLS},
Diacylglycerol (DAG) was discovered as a potent lipid second messenger with protein kinase C (PKC) as its major cellular target more than 25 years ago. There is increasing evidence of significant complexity within lipid signaling, and the classical DAG-PKC model no longer stands alone but is part of a larger bioactive lipid universe involving glycerolipids and sphingolipids. Multiple layers of regulation exist among PKC- and DAG-metabolizing enzymes such as phosphatidylcholine (PC)-specific… CONTINUE READING


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