Protein kinase C and oxidative stress in an animal model of mania.

  title={Protein kinase C and oxidative stress in an animal model of mania.},
  author={Amanda Valnier Steckert and Samira S Valvassori and Francielle Mina and J{\'e}ssica Lopes-Borges and Roger Bitencourt Varela and Fl{\'a}vio Kapczinski and Felipe Dal-Pizzol and Jo{\~a}o Quevedo},
  journal={Current neurovascular research},
  volume={9 1},
The present study aims to investigate the effects of protein kinase C using the inhibitor Tamoxifen (TMX) on oxidative stress in a rat animal model of mania induced by d-amphetamine (d-AMPH). In the reversal model, d-AMPH or saline (Sal) were administered to rats for 14 days, and between days 8-14, rats were treated with TMX or Sal. In the prevention model, rats were pretreated with TMX or Sal, and between days 8-14, d-AMPH or Sal were administrated. In both experiments locomotor activity and… CONTINUE READING


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