Protein kinase C and lipid signaling for sustained cellular responses

  title={Protein kinase C and lipid signaling for sustained cellular responses},
  author={Yasutomi Nishizuka},
  journal={The FASEB Journal},
  pages={484 - 496}
Since the second messenger role was proposed for the products of inositol phospholipid hydrolysis, considerable progress has been made in our understanding of the biochemical mechanism of the intracellular signaling network. It is now becoming evident that stimulation of a cell surface receptor initiates a degradation cascade of various membrane lipid constituents. Many of their metabolites have potentials to induce, intensify, and prolong the activation of protein kinase C that is needed for… 
Phosphatidylcholine hydrolysis and protein kinase C activation for intracellular signaling network.
  • S. Nakamura
  • Biology, Chemistry
    Journal of lipid mediators and cell signalling
  • 1996
The family of protein kinase C and membrane lipid mediators.
Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids
This chapter focuses on the molecular mechanisms by which phosphorylation and lipid binding control protein kinase C.
Lipid Signaling for Protein Kinase C Activation
This chapter will describe the signal-induced degradation of various membrane phospholipids that play a role in transmitting information from extracellular signals across the cell membrane.
Regulation of protein kinase C.
  • A. Newton
  • Biology
    Current opinion in cell biology
  • 1997
Regulation of protein kinase
Protein kinase C has been in the spotlight since the discovery two decades ago that it is activated by the lipid second messenger diacylglycerol, and the discovery that phosphorylation regulates the enzyme has made the past year a significant one for unveiling how this ubiquitous class of enzymes operates.
Analyzing protein kinase C activation.
The Ca2+‐activated, phospholipid‐dependent protein kinase discovered by Nishizuka's group in 1977 is now a family of at least 11 isoforms, and each isoform has a characteristic subcellular distribution in each cell type.
Intracellular transport mechanisms of signal transducers.
The pathophysiological significance of disrupted subcellular protein transport in cell signaling and the potential therapeutic utility of targeted regulation of these events are in the process of being characterized.
Signaling through protein kinase C.
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  • Biology, Computer Science
    Frontiers in bioscience : a journal and virtual library
  • 1998
This review will focus on recent findings on the mechanism of regulation of PKCepsilon, PKCmu and PKCzeta, and how these enzymes regulate cell growth, the actin cytoskeleton, apoptosis and other biological functions.