Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.

@article{Amos2007ProteinKC,
  title={Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.},
  author={Samson Amos and Melike Mut and Charles G Dipierro and Joan E. Carpenter and Aizhen Xiao and Zachary A Kohutek and Gerard T. Redpath and Yun-ge Zhao and Jiahu Wang and Mark E. Shaffrey and Isa Marte Hussaini},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={
          10241-51
        }
}
Aggressive and infiltrative invasion is one of the hallmarks of glioblastoma. Low-density lipoprotein receptor-related protein (LRP) is expressed by glioblastoma, but the role of this receptor in astrocytic tumor invasion remains poorly understood. We show that activation of protein kinase C-alpha (PKC-alpha) phosphorylated and down-regulated LRP expression. Pretreatment of tumor cells with PKC inhibitors, phosphoinositide 3-kinase (PI3K) inhibitor, PKC-alpha small interfering RNA (siRNA), and… CONTINUE READING

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1 Excerpt