Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma.

@article{Chuize2010ProteinKC,
  title={Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma.},
  author={Kong Chuize and Zhu Yuyan and Zhang Zhe and Liu Tao and Yu Meng and Yang Qi},
  journal={Urology},
  year={2010},
  volume={76 2},
  pages={514.e1-5}
}
OBJECTIVES To evaluate protein kinase C-alpha (PKCalpha) expression in human renal cell carcinoma (RCC) tissues and cell lines, and its clinical significance. METHODS Expression of PKCalpha was analyzed by Western blot in 90 clinical specimens. The expression of PKCalpha in the cytoplasm or plasma membrane was correlated to clinical stage and grade to assess for potential relationships. A human renal cell carcinoma (RCC) cell line (786-O/PKCalpha) was generated with stable expression of a… CONTINUE READING