Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.

@article{Haughian2009ProteinKC,
  title={Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.},
  author={James M. Haughian and Elaine M. Reno and Alicia M. Thorne and Andrew P Bradford},
  journal={International journal of cancer},
  year={2009},
  volume={125 11},
  pages={
          2556-64
        }
}
Endometrial cancer is the most common invasive gynecologic malignancy, yet molecular mechanisms and signaling pathways underlying its etiology and pathophysiology remain poorly characterized. We sought to define a functional role for the protein kinase C (PKC) isoform, PKCalpha, in an established cell model of endometrial adenocarcinoma. Ishikawa cells depleted of PKCalpha protein grew slower, formed fewer colonies in anchorage-independent growth assays and exhibited impaired xenograft tumor… CONTINUE READING

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