Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells.

@article{CastroGalache2007ProteinKC,
  title={Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells.},
  author={Mar{\'i}a D Castro-Galache and Mar{\'i}a P Men{\'e}ndez-Guti{\'e}rrez and Estefania Carrasco Garcia and Pilar Garc{\'i}a-Morales and Isabel Mart{\'i}nez-Lacaci and Miguel Saceda and Jos{\'e} Antonio Ferragut},
  journal={The international journal of biochemistry & cell biology},
  year={2007},
  volume={39 10},
  pages={1877-85}
}
Previous studies have documented that while several drug-resistant cells enter apoptosis upon treatment with histone deacetylase inhibitors (iHDACs), their drug-sensitive counterparts do not. In the present study, we have investigated at the molecular level why parental drug-sensitive tumor cells do not respond to Trichostatin A and suberoylanilide hydroxamic acid, two iHDACs that promote apoptosis in drug-resistant leukaemia cells. Taking murine leukaemia L1210 cells as a model, we have… CONTINUE READING