Protein kinase C activity modulates dendritic differentiation of rat Purkinje cells in cerebellar slice cultures.

@article{Metzger2000ProteinKC,
  title={Protein kinase C activity modulates dendritic differentiation of rat Purkinje cells in cerebellar slice cultures.},
  author={Friedrich Metzger and Josef P. Kapfhammer},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 6},
  pages={1993-2005}
}
The molecular mechanisms underlying dendritic differentiation in neurons are currently poorly understood. We used slice cultures from rat cerebellum of postnatal day 8 to investigate the effect of protein kinase C (PKC) activity on dendritic development of Purkinje cells. After 12 days in culture under control conditions, Purkinje cells had developed a typical dendritic tree consisting of a few long primary dendrites with shorter side branches. Following treatment with the PKC agonist, phorbol… CONTINUE READING

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