Protein kinase C activity is associated with prefrontal cortical decline in aging.

@article{Brennan2009ProteinKC,
  title={Protein kinase C activity is associated with prefrontal cortical decline in aging.},
  author={Avis R. Brennan and Peixiong Yuan and Dara L. Dickstein and Anne B. Rocher and Patrick R. Hof and Husseini K. Manji and Amy F. T. Arnsten},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 5},
  pages={782-92}
}
Aging is associated with deficiencies in the prefrontal cortex, including working memory impairment and compromised integrity of neuronal dendrites. Although protein kinase C (PKC) is implicated in structural plasticity, and overactivation of PKC results in working memory impairments in young animals, the role of PKC in prefrontal cortical impairments in the aged has not been examined. This study provides the first evidence that PKC activity is associated with prefrontal cortical dysfunction in… CONTINUE READING

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