Protein kinase C activity in mouse eggs regulates gamete membrane interaction

@article{Akabane2007ProteinKC,
  title={Protein kinase C activity in mouse eggs regulates gamete membrane interaction},
  author={Hiroto Akabane and Jun Fan and Xue-cheng Zheng and Guo-Zhang Zhu},
  journal={Molecular Reproduction and Development},
  year={2007},
  volume={74}
}
Gamete membrane interaction is critical to initiate the development of a new organism. The signaling pathways governing this event, however, are poorly understood. In this report, we provide the first evidence that protein kinase C activity in mouse eggs plays a crucial role in the regulation of this process. Stimulating PKC activity in mouse eggs by phorbol 12‐myristate 13‐acetate (PMA) drastically inhibited the egg's membrane ability to bind and fuse with sperm. Surprisingly, this significant… 
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