Protein kinase C activation during corneal endothelial wound repair.

  title={Protein kinase C activation during corneal endothelial wound repair.},
  author={Nancy C. Joyce and B Meklir},
  journal={Investigative ophthalmology & visual science},
  volume={33 6},
In previous studies, the authors have shown that the two forms of cell translocation that occur during corneal endothelial monolayer wound repair can be pharmacologically separated. Epidermal growth factor (EGF) enhanced the breaking of cell-cell contacts and movement of individual cells from the wound edge, while indomethacin, an inhibitor of PGE2 synthesis, promoted cell enlargement and spreading of the confluent monolayer sheet into the wound defect. From these findings, the authors… CONTINUE READING


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