Protein kinase C activation causes neurite retraction via cyclinD1 and p60-katanin increase in rat hippocampal neurons.

@article{Korulu2013ProteinKC,
  title={Protein kinase C activation causes neurite retraction via cyclinD1 and p60-katanin increase in rat hippocampal neurons.},
  author={Sirin Korulu and Aysegul Yildiz-Unal and Meral Yūksel and Arzu Karabay},
  journal={The European journal of neuroscience},
  year={2013},
  volume={37 10},
  pages={1610-9}
}
Neurons are differentiated postmitotic cells residing in G0 phase of the cell cycle and are unable to proceed through G1 phase, in which cyclinD1 needs to be up-regulated for initiation. Yet, a growing body of evidence has shown that cell cycle re-activation via cyclinD1 up-regulation drives neurons into apoptosis. By contrast, there is also evidence demonstrating cell cycle proteins playing roles in neuronal differentiation. cyclinD1 has been shown to be differently regulated by protein kinase… CONTINUE READING

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