Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.

@article{Dechecchi1993ProteinKC,
  title={Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene.},
  author={Maria Cristina Dechecchi and Anna Tamanini and Giorgio Berton and Giulio Cabrini},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 15},
  pages={11321-5}
}
The regulatory domain (R domain) of the cystic fibrosis transmembrane conductance regulator (CFTR) is phosphorylated by protein kinase A and protein kinase C (PKC) in vivo (Picciotto, M. R., Cohn, J. A., Bertuzzi, G., Greengard, P., and Nairn, A. C. (1992) J. Biol. Chem. 267, 12742-12752), but so far the functional effect of the PKC-dependent phosphorylation has not been clarified. We investigated the effect of PKC on the CFTR-mediated Cl- transport by treating with phorbol 12-myristate 13… CONTINUE READING

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