Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes.

Abstract

Kidney disease has been linked to dysregulated signaling via PKC in kidney cells such as podocytes. PKCα is a conventional isoform of PKC and a well-known binding partner of β-catenin, which promotes its degradation. β-Catenin is the main effector of the canonical Wnt pathway and is critical in cell adhesion. However, whether other PKC isoforms interact… (More)
DOI: 10.1074/jbc.M117.775700

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