Protein kinase C β inhibition: the promise for treatment of diabetic nephropathy

@article{Anderson2007ProteinKC,
  title={Protein kinase C $\beta$ inhibition: the promise for treatment of diabetic nephropathy},
  author={Pamela W. Anderson and Janet B. McGill and Katherine R. Tuttle},
  journal={Current Opinion in Nephrology and Hypertension},
  year={2007},
  volume={16},
  pages={397–402}
}
Purpose of reviewThe prevalence of diabetes mellitus is increasing rapidly worldwide. The number of patients with diabetic nephropathy is also expected to increase considerably in the future despite currently available treatments that may prevent or slow kidney disease progression. Additional therapeutic agents are therefore urgently needed. Recent findingsRuboxistaurin mesylate is a bisindolylmaleimide that specifically inhibits the β-isoform of protein kinase C. In animal models of diabetic… 
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