Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.

@article{Condorelli2001ProteinKC,
  title={Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells.},
  author={Gerolama Condorelli and Giovanni Vigliotta and Alessandra Trencia and Maria Alessandra Maitan and Massimo Caruso and Claudia Miele and Francesco Oriente and Stefania Santopietro and Pietro Formisano and Francesco B{\'e}guinot},
  journal={Diabetes},
  year={2001},
  volume={50 6},
  pages={1244-52}
}
Overexpression of the PED/PEA-15 protein in muscle and adipose cells increases glucose transport and impairs further insulin induction. Like glucose transport, protein kinase C (PKC)-alpha and -beta are also constitutively activated and are not further stimulatable by insulin in L6 skeletal muscle cells overexpressing PED (L6(PED)). PKC-zeta features no basal change but completely loses insulin sensitivity in L6(PED). In these cells, blockage of PKC-alpha and -beta additively returns 2-deoxy-D… CONTINUE READING
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