Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

@article{Gordon2016ProteinKC,
  title={Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease},
  author={Richard Gordon and Neeraj Singh and Vivek Lawana and Anamitra Ghosh and Arthi Kanthasamy},
  journal={Neurobiology of Disease},
  year={2016},
  volume={93},
  pages={96-114}
}
Chronic microglial activation has been linked to the progressive degeneration of the nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis. The exact etiology of PD remains poorly understood. Although both oxidative stress and neuroinflammation are identified as co-contributors in PD pathogenesis, signaling mechanisms underlying neurodegenerative processes have yet to be defined. Indeed, we recently identified that protein kinase C delta (PKCδ) activation is… CONTINUE READING

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