Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.

@article{Limnander2014ProteinKC,
  title={Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.},
  author={Andr{\'e} Limnander and Julie Zikherman and Tannia Lau and Michael Leitges and Arthur Weiss and Jeroen P Roose},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 8},
  pages={1474-85}
}
Protein kinase Cδ (PKCδ) deficiency causes autoimmune pathology in humans and mice and is crucial for the maintenance of B cell homeostasis. However, the mechanisms underlying autoimmune disease in PKCδ deficiency remain poorly defined. Here, we address the antigen-dependent and -independent roles of PKCδ in B cell development, repertoire selection, and antigen responsiveness. We demonstrate that PKCδ is rapidly phosphorylated downstream of both the B cell receptor (BCR) and the B cell… CONTINUE READING