Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling

  title={Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling},
  author={Miho Kubo-Murai and K. Hazeki and Naoe Sukenobu and K. Yoshikawa and K. Nigorikawa and Kazumi Inoue and T. Yamamoto and M. Matsumoto and T. Seya and N. Inoue and O. Hazeki},
  journal={Molecular Immunology},
  • Miho Kubo-Murai, K. Hazeki, +8 authors O. Hazeki
  • Published 2007
  • Chemistry
  • Molecular Immunology
  • Toll-like receptor (TLR) family members recognize specific molecular patterns within pathogens. Signaling through TLRs results in a proximal event that involves direct binding of adaptor proteins to the receptors. We observed that TIRAP/Mal, an adaptor protein for TLR2 and TLR4, binds protein kinase Cdelta (PKCdelta). TIRAP/Mal GST-fusion protein and a TIRAP/Mal antibody were able to precipitate PKCdelta from rat peritoneal macrophage and THP1 cell lysates. Truncation mutants of TIRAP/Mal… CONTINUE READING
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