Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

@article{Hill2014ProteinKC,
  title={Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis},
  author={Kristen S. Hill and Eda Erdogan and Andr{\'a}s Kho{\'o}r and M. P. Walsh and Michael Leitges and Nicole R. Murray and Alan P. Fields},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={2134-2144}
}
Protein kinase C alpha (PKCα) can activate both pro- and anti-tumorigenic signaling depending upon cellular context. Here, we investigated the role of PKCα in lung tumorigenesis in vivo. Gene expression data sets revealed that primary human non-small lung cancers (NSCLC) express significantly decreased PKCα levels, indicating that loss of PKCα expression is a recurrent event in NSCLC. We evaluated the functional relevance of PKCα loss during lung tumorigenesis in three murine lung… CONTINUE READING

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