Protein kinase C(theta) in T cell activation.

  title={Protein kinase C(theta) in T cell activation.},
  author={Noah Isakov and Amnon Altman},
  journal={Annual review of immunology},
The novel protein kinase C (PKC) isoform, PKC theta, is selectively expressed in T lymphocytes and is a sine qua non for T cell antigen receptor (TCR)-triggered activation of mature T cells. Productive engagement of T cells by antigen-presenting cells (APCs) results in recruitment of PKC theta to the T cell-APC contact area--the immunological synapse--where… CONTINUE READING