Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation.

@article{Dufner1999ProteinKB,
  title={Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation.},
  author={Almut Dufner and Mirjana Andjelkovic and Boudewijn M. T. Burgering and Brian A. Hemmings and George Thomas},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 6},
  pages={4525-34}
}
Recent studies indicate that phosphatidylinositide-3OH kinase (PI3K)-induced S6 kinase (S6K1) activation is mediated by protein kinase B (PKB). Support for this hypothesis has largely relied on results obtained with highly active, constitutively membrane-localized alleles of wild-type PKB, whose activity is independent of PI3K. Here we set out to examine the importance of PKB signaling in S6K1 activation. In parallel, glycogen synthase kinase 3beta (GSK-3beta) inactivation and eukaryotic… CONTINUE READING

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