Protein kinase B in the diabetic heart

  title={Protein kinase B in the diabetic heart},
  author={Barbara Huisamen},
  journal={Molecular and Cellular Biochemistry},
This paper summarizes data from different studies all aimed at elucidating regulation of protein kinase B in the diabetic heart. Two rat models of type 2 diabetes mellitus ((i) elicited via neonatal streptozotocin injection (Stz) and (ii) Zucker fa/fa rats), were used as well as different experimental models viz isolated, Langendorff perfused hearts as well as adult ventricular myocytes. Glucose uptake was elicited by a variety of stimuli and the activation of PKB measured in tandem. Basal… CONTINUE READING
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