Protein kinase B beta/Akt2 plays a specific role in muscle differentiation.

@article{Vandromme2001ProteinKB,
  title={Protein kinase B beta/Akt2 plays a specific role in muscle differentiation.},
  author={Marie Vandromme and Anne Rochat and R. C. Meier and Gilles Carnac and Daniel Besser and Brian A. Hemmings and Anne Fernandez and Ned J. C. Lamb},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 11},
  pages={8173-9}
}
Insulin-like growth factors positively regulate muscle differentiation through activation of the phosphatidylinositol 3-kinase/protein kinase B (PKB/Akt) signaling pathway. Here, we compare the role of the two closely related alpha (Akt1) and beta (Akt2) isoforms of PKB in muscle differentiation. During differentiation of C2.7 or L6D2 myoblasts, PKBbeta was up-regulated whereas expression of PKBalpha was unaltered. Although the two isoforms were found active in both myoblasts and myotubes, cell… CONTINUE READING
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