Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway.

@article{Welch1998ProteinKB,
  title={Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway.},
  author={Heidi C E Welch and Alicia Eguinoa and Len R. Stephens and Phillip T. Hawkins},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 18},
  pages={11248-56}
}
The GTPase Rac and the protein kinase B (PKB) are downstream targets of phosphatidylinositide 3OH-kinase in platelet-derived growth factor-stimulated signaling pathways. We have generated PAE cell lines inducibly expressing mutants of Rac. Use of these cell lines suggests that Rac is involved in both platelet-derived growth factor-stimulated membrane ruffling and the activation of p70(S6K) but not in the activation of PKB. Furthermore, expression of constitutively active alleles of PKB in PAE… CONTINUE READING

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