Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

@article{HaasKogan1998ProteinKB,
  title={Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC},
  author={Daphne Adele Haas-Kogan and Noga Shalev and Michelle Wong and Gordon Mills and Garret L. Yount and David Stokoe},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={1195-S1}
}
Glioblastomas are highly malignant tumors of the central nervous system that are resistant to radiation and chemotherapy [1]. We explored the role of the phosphatidylinositol (PI) 3-kinase signal transduction pathway in glioblastomas, as this pathway has been shown to inhibit apoptosis induced by cytokine withdrawal and the detachment of cells from the extracellular matrix [2]. Components of this pathway have been implicated in tumor development [3-6]. We show that glioblastoma cells, in… CONTINUE READING
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