Protein kinase B (AKT1) genotype mediates sensitivity to cannabis-induced impairments in psychomotor control

@article{Bhattacharyya2014ProteinKB,
  title={Protein kinase B (AKT1) genotype mediates sensitivity to cannabis-induced impairments in psychomotor control},
  author={Sagnik Bhattacharyya and Conrad Osamede Iyegbe and Zerrin Atakan and Roc{\'i}o Mart{\'i}n-Santos and Jos{\'e} A. S. Crippa and X M Xu and S. Williams and Michael J. Brammer and Katya Rubia and Diana P. Prata and David A. Collier and Philip K. McGuire},
  journal={Psychological Medicine},
  year={2014},
  volume={44},
  pages={3315 - 3328}
}
Background. What determines inter-individual variability to impairments in behavioural control that may underlie road-traffic accidents, and impulsive and violent behaviours occurring under the influence of cannabis, the most widely used illicit drug worldwide? Method. Employing a double-blind, repeated-measures design, we investigated the genetic and neural basis of variable sensitivity to cannabis-induced behavioural dyscontrol in healthy occasional cannabis users. Acute oral challenge with… 
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