Protein kinase B (AKT1) genotype mediates sensitivity to cannabis-induced impairments in psychomotor control

  title={Protein kinase B (AKT1) genotype mediates sensitivity to cannabis-induced impairments in psychomotor control},
  author={Sagnik Bhattacharyya and Conrad Osamede Iyegbe and Zerrin Atakan and Roc{\'i}o Mart{\'i}n-Santos and Jos{\'e} A. S. Crippa and X M Xu and S. Williams and Michael J. Brammer and Katya Rubia and Diana P. Prata and David A. Collier and Philip K. McGuire},
  journal={Psychological Medicine},
  pages={3315 - 3328}
Background. What determines inter-individual variability to impairments in behavioural control that may underlie road-traffic accidents, and impulsive and violent behaviours occurring under the influence of cannabis, the most widely used illicit drug worldwide? Method. Employing a double-blind, repeated-measures design, we investigated the genetic and neural basis of variable sensitivity to cannabis-induced behavioural dyscontrol in healthy occasional cannabis users. Acute oral challenge with… 
The effect of the AKT1 gene and cannabis use on cognitive performance in healthy subjects
This study provides additional evidence that AKT1 modulates cognitive performance, however, in the non-clinical sample, the previously reported interaction between cannabis use and theAKT1 gene was not replicated.
Epigenetic Mediation of AKT1 rs1130233’s Effect on Delta-9-Tetrahydrocannabinol-Induced Medial Temporal Function during Fear Processing
The genetic (AKT1 rs1130233) and epigenetic modulation of brain function during fear processing in a 2-session, double-blind, cross-over, randomized placebo-controlled THC administration, in 36 healthy males may offer an example of how genetic and methylation variations influence the psychotomimetic and neurofunctional effects of THC.
The effect of interactions between genetics and cannabis use on neurocognition. A review
Increased hippocampal engagement during learning as a marker of sensitivity to psychotomimetic effects of δ-9-THC
Results suggest that altered hippocampal activation during verbal encoding may serve as a marker of sensitivity to the acute psychotomimetic effects of THC.
The neuropsychopharmacology of cannabis: A review of human imaging studies
Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence
Does cannabis affect dopaminergic signaling in the human brain? A systematic review of evidence to date
Impact of At Least 2 Years of Synthetic Cannabinoid Use on Cognitive and Psychomotor Functions Among Treatment-Seeking Male Outpatients.
It is suggested that outpatients with SC use disorder should be carefully evaluated for cognitive and psychomotor functions since neurological examinations and interventions may also be required in treatment programs for these cases.


AKT1 Moderation of Cannabis-Induced Cognitive Alterations in Psychotic Disorder
It is suggested that long-term changes in cognition may mediate the risk-increasing effect of the AKT1 × cannabis interaction on psychotic disorder, and cannabis use before onset of psychosis may have long-lasting effects on measures of sustained attention, even in the absence of current use.
Confirmation that the AKT1 (rs2494732) Genotype Influences the Risk of Psychosis in Cannabis Users
DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia
The present results indicate that these functional polymorphisms are epistatically associated with multiple phenotypes of relevance to schizophrenia and lend support to further investigation of this downstream molecular pathway in the etiology and treatment of this disorder.
Cannabis use is associated with schizotypy and attentional disinhibition
Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins
  • O. Pietiläinen, T. Paunio, L. Peltonen
  • Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2009
The established association of the same allelic variant of AKT1 with both cognitive and neuroanatomical aberrations could suggest thatAKT1 exerts its effect on verbal learning and memory via neural networks involving prefrontal cortex.
Δ9-Tetrahydrocannabinol Induces Dopamine Release in the Human Striatum
It is shown that Δ9-tetrahydrocannabinol (THC), the main psychoactive component in cannabis, induces dopamine release in the human striatum, implying that the endogenous cannabinoid system is involved in regulating striatal dopamine release.
Cannabis induced dopamine release: an in-vivo SPECT study
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
The data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia.
Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing.
CONTEXT The aberrant processing of salience is thought to be a fundamental factor underlying psychosis. Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of
Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis.
The modulation of mediotemporal and ventrostriatal function by Delta9-THC may underlie the effects of C. sativa on verbal learning and psychotic symptoms, respectively.