Protein kinase A type I: a target for cancer therapy.

  title={Protein kinase A type I: a target for cancer therapy.},
  author={Giampaolo Tortora and Fortunato Ciardiello},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={8 2},
The mechanism of action of the two isoforms of the PKA, defined PKAI and PKAII, respectively, has been the object of study for almost 25 years. However, only during the past decade, experimental evidences have started to confer distinct functions to PKAI and PKAII and have demonstrated that their intracellular balanced expression may play a critical role in… CONTINUE READING