Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1.

@article{Moir2006ProteinKA,
  title={Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1.},
  author={Robyn D. Moir and Jaehoon Lee and Rebecca A. Haeusler and Neelam V Desai and David Engelke and Ian M. Willis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 41},
  pages={15044-9}
}
Maf1 is an essential and specific mediator of transcriptional repression in the RNA polymerase (pol) III system. Maf1-dependent repression occurs in response to a wide range of conditions, suggesting that the protein itself is targeted by the major nutritional and stress-signaling pathways. We show that Maf1 is a substrate for cAMP-dependent PKA in vitro and is differentially phosphorylated on PKA sites in vivo under normal versus repressing conditions. PKA activity negatively regulates Maf1… CONTINUE READING
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