Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.

@article{Yoon2008ProteinKA,
  title={Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.},
  author={Cho-Ya Yoon and Zeljka Korade and Bruce D Carter},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 14},
  pages={
          3738-46
        }
}
  • Cho-Ya Yoon, Zeljka Korade, Bruce D Carter
  • Published in
    The Journal of neuroscience…
    2008
  • Biology, Medicine
  • Axon-Schwann cell interactions are critical for myelin formation during peripheral nerve development and regeneration. Axonal contact promotes Schwann cell precursors to differentiate into a myelinating phenotype, and cAMP-elevating agents can mimic this; however, the mechanisms underlying this differentiation are poorly understood. We demonstrated previously that the transcription factor nuclear factor-kappaB (NF-kappaB) is required for myelin formation by Schwann cells (Nickols et al., 2003… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 53 CITATIONS, ESTIMATED 55% COVERAGE

    NF-κB forms a complex with the chromatin remodeler BRG1 to regulate Schwann cell differentiation.

    VIEW 8 EXCERPTS
    CITES BACKGROUND & METHODS

    Expressions of Forkhead Class Box O 3a on Crushed Rat Sciatic Nerves and Differentiated Primary Schwann cells

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    KATP channel action in vascular tone regulation during septic shock: Beyond physiology

    VIEW 4 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    Mouse schwann cells need both NRG1 and cyclic AMP to myelinate.

    VIEW 20 EXCERPTS
    CITES BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    Molecular Mechanisms Involved in Schwann Cell Plasticity

    VIEW 1 EXCERPT
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2008
    2018

    CITATION STATISTICS

    • 6 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES

    Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL

    Axons regulate Schwann cell expression of the major myelin and NGF receptor genes.

    VIEW 6 EXCERPTS
    HIGHLY INFLUENTIAL

    Retroviral inhibition of cAMP-dependent protein kinase inhibits myelination but not Schwann cell mitosis stimulated by interaction with neurons.

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Differential serine phosphorylation regulates IkappaB-alpha inactivation.

    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL