Protein kinase A and hedgehog signaling in drosophila limb development

  title={Protein kinase A and hedgehog signaling in drosophila limb development},
  author={Jin Jiang and Gary Struhl},
The Drosophila hedgehog (hh) gene encodes a secreted protein involved in organizing growth and patterning in many developmental processes. Hh appears to act by inducing the localized expression of at least two other signaling molecules, decapentaplegic (dpp) and wingless (wg), which then govern cell proliferation and patterning in surrounding tissue. Here, we demonstrate that cyclic AMP (cAMP)-dependent protein kinase A (PKA) is essential during limb development to prevent inappropriate dpp and… CONTINUE READING
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  • G. Struhl, K. Basler
  • 1993
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