Protein kinase A and chromosomal stability.

  title={Protein kinase A and chromosomal stability.},
  author={Ludmila Matyakhina and Sara M. Lenherr and Constantine A Stratakis},
  journal={Annals of the New York Academy of Sciences},
All malignant human tumors contain chromosomal rearrangements. Among them, the majority of solid tumors show chromosomal instability, caused by aberrations in chromosomal segregation during cell division. Chromosomal instability, defined as increased probability of formation of novel chromosomal mutations compared to that of normal or control cells, appears to be a feature of tumorigenesis in vivo and in vitro (in cancer cell lines). Several enzymatic kinases are involved in maintaining proper… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations

Extracellular activity of cyclic AMP-dependent protein kinase as a biomarker for human cancer detection: distribution characteristics in a normal population and cancer patients.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…