Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility.

@article{Vijayaraghavan1997ProteinKA,
  title={Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility.},
  author={Sumitra Vijayaraghavan and Said A. Goueli and Michael P Davey and Daniel J J Carr},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 8},
  pages={4747-52}
}
Cyclic AMP-dependent protein kinase (PKA) is anchored at specific subcellular sites through the interaction of the regulatory subunit (R) with protein kinase A-anchoring proteins (AKAPs) via an amphipathic helix binding motif. Synthetic peptides containing this amphipathic helix domain competitively disrupt PKA binding to AKAPs and cause a loss of PKA modulation of cellular responses. In this report we use S-Ht31, a cell-permeant anchoring inhibitor peptide, to study the role of PKA anchoring… CONTINUE READING
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