Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network.

@article{Muiz1997ProteinKA,
  title={Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network.},
  author={Manuel Mu{\~n}iz and Mar{\'i}a Esther Mart{\'i}n and J. R. Hidalgo and Angel Velasco},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 26},
  pages={14461-6}
}
We have examined the role played by protein kinase A (PKA) in vesicle-mediated protein transport from the trans-Golgi network (TGN) to the cell surface. In vivo this transport step was inhibited by inhibitors of PKA catalytic subunits (C-PKA) such as the compound known as H89 and a myristoylated form of the inhibitory peptide sequence contained in the thermostable PKA inhibitor. Inhibition by H89 occurred at an early stage during the transfer of vesicular stomatitis virus G glycoprotein from… CONTINUE READING

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Muñiz et al

  • J. L. Rosa, R. P. Casaroli-Marano, +4 authors 4262–4273. 14466 Cell Biology
  • Proc. Natl. Acad. Sci. USA 94
  • 1997

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