Protein kinase A–dependent modulation of Ca2+ sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin

@inproceedings{Matsuba2009ProteinKA,
  title={Protein kinase A–dependent modulation of Ca2+ sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin},
  author={Douchi Matsuba and Takako Terui and Jin O-Uchi and Hiroyuki Tanaka and Takao Ojima and Iwao Ohtsuki and Shin'ichi Ishiwata and Satoshi Kurihara and Norio Fukuda},
  booktitle={The Journal of general physiology},
  year={2009}
}
Protein kinase A (PKA)-dependent phosphorylation of troponin (Tn)I represents a major physiological mechanism during beta-adrenergic stimulation in myocardium for the reduction of myofibrillar Ca2+ sensitivity via weakening of the interaction with TnC. By taking advantage of thin filament reconstitution, we directly investigated whether or not PKA-dependent phosphorylation of cardiac TnI (cTnI) decreases Ca2+ sensitivity in different types of muscle: cardiac (porcine ventricular) and fast… CONTINUE READING
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