Protein kinase A(PKA)-restrictive and PKA-permissive phases of oocyte maturation.

@article{Wang2006ProteinKA,
  title={Protein kinase A(PKA)-restrictive and PKA-permissive phases of oocyte maturation.},
  author={Jing Wang and Winnie Li Cao and Xiangyang Liu},
  journal={Cell cycle},
  year={2006},
  volume={5 2},
  pages={213-7}
}
Substantial evidence has indicated that cAMP-dependent protein kinase (protein kinase A or PKA) plays a critical role in maintaining meiotic prophase arrest in vertebrate oocytes. However, PKA activity dynamic and its physiological substrate profile during oocyte maturation remain poorly defined. We have recently developed a novel PKA substrate construct which we employ to monitor PKA activity in live oocytes. We demonstrated here that, during progesterone-induced oocyte maturation, PKA was… CONTINUE READING