Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.

@article{Jeong2018ProteinKM,
  title={Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.},
  author={Dongjun Jeong and Hyeongjoo Kim and Doyeon Kim and Seona Ban and Seunghyun Oh and Sanghee Ji and Dong-Ii Kang and Hyunyong Lee and Tae Sung Ahn and Han Jo Kim and Sang Byung Bae and Moon-Soo Lee and Changjin Kim and Hyog Young Kwon and Moo-Jun Baek},
  journal={Oncology reports},
  year={2018},
  volume={39 6},
  pages={
          2829-2836
        }
}
The protein kinase, membrane‑associated tyrosine/threonine 1 (PKMYT1) is known to inhibit precocious entry into mitosis by phosphorylating CDK1 at Thr14 and Tyr15 residues. However, the functional importance of PKMYT1 in colorectal cancer (CRC) remains unknown. Thus, it is important to elucidate whether PKYMT1 is indispensable in the tumorigenesis of CRC. To investigate the functional importance of PKMYT1 in CRC tumorigenesis, PKMYT1 was knocked down in CRC cell lines such as SW480, SW620… 

Figures and Tables from this paper

PKMYT1 Promotes Gastric Cancer Cell Proliferation and Apoptosis Resistance

TLDR
It is suggested that PKMYT1 promotes cell proliferation and apoptosis resistance in GC cells by activating the MAPK signaling pathway, making it a potential therapeutic target for GC.

OTT_A_255746 7747..7757

TLDR
It is suggested that PKMYT1 promotes cell proliferation and apoptosis resistance in GC cells by activating the MAPK signaling pathway, making it a potential therapeutic target for GC.

A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target

TLDR
This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with a focus on their dual role as tumor suppressors in nonmalignant cells and pseudo-oncogenes in cancer cells.

Overexpression of PKMYT1 Facilitates Tumor Development and Is Correlated with Poor Prognosis in Clear Cell Renal Cell Carcinoma

  • P. ChenZiying ZhangXiang Chen
  • Biology, Medicine
    Medical science monitor : international medical journal of experimental and clinical research
  • 2020
Background Protein kinase membrane-associated tyrosine/threonine (PKMYT1) has been found in many tumors, but its association with clear cell renal cell carcinoma (ccRCC) remains unclear.

Expression of Spermine Oxidase Is Associated with Colorectal Carcinogenesis and Prognosis of Patients

TLDR
It is indicated that SMOX overexpression could be an important oncogene in CRC and might serve as a valuable prognostic marker and potential therapeutic target for CRC.

Overexpressed PKMYT1 promotes tumor progression and associates with poor survival in esophageal squamous cell carcinoma

Background Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors worldwide and the 5-year overall survival rate remains poor. Protein kinase, membrane associated

Upregulation of Myt1 promotes acquired resistance of cancer cells to Wee1 inhibition.

TLDR
It is demonstrated that upregulating Myt1 is a mechanism by which cancer cells acquire resistance to Adavosertib, and downregulating myt1 enhanced ectopic Cdk1 activity and restored sensitivity to Advosert ib.

c-Myb-mediated inhibition of miR-601 in facilitating malignance of osteosarcoma via augmentation of PKMYT1

TLDR
The studies reveal that miR-601 is a suppressive gene negatively correlated with malignancy of OS and is downregulated in both OS cells and tissues.

References

SHOWING 1-10 OF 35 REFERENCES

Regulation of the human WEE1Hu CDK tyrosine 15‐kinase during the cell cycle.

TLDR
The results suggest that the activity of WEE1Hu is regulated by phosphorylation and proteolytic degradation, and that Wee1Hu plays a role in inhibiting mitosis before M phase byosphorylating cyclin B1‐Cdc2.

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

TLDR
Immunodepletion studies suggested that Myt1 is the predominant threonine-14-specific kinase in Xenopus egg extracts, suggesting that this relative of Wee1 plays a role in mitotic control.

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

TLDR
The isolation of a novel human cDNA encoding a dual-specificity protein kinase (designated Myt1Hu) that preferentially phosphorylates Cdc2 on threonine 14 in a cyclin-dependent manner is reported.

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

TLDR
It is shown that residues Thr14 and Tyr15 of mouse p34cdc2 become phosphorylated as mouse fibroblasts proceed through the cell cycle, suggesting that these phosphorylation events form part of the pathway linking completion of DNA replication to initiation of mitosis.

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

TLDR
The mechanistic coupling between EMT and resistance to anoikis is reviewed, and unifying principles that will lead to improvements in cancer therapy by reprogramming sensitivity of anoIKis are identified.

c-Jun N-Terminal Kinase 1 Phosphorylates Myt1 To Prevent UVA-Induced Skin Cancer

TLDR
Mechanistic insights into the distinct roles of the different JNK isoforms are provided, specifically suggesting that the JNK1-mediated phosphorylation of Myt1 plays an important role in UVA-induced apoptosis and the prevention of skin carcinogenesis.

The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery

TLDR
The functions of MYT1 in checkpoint recovery are revealed and the potential of myT1 as a target for anti-cancer therapies is highlighted.

Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer

TLDR
Pathway analysis of the target genes regulated by the five most highly expressed miRNAs uncovered a significant number of genes involved in the CRC pathway, including APC, TGFβ and PI3K, thus suggesting that these miRNAAs are relevant in CRC.

The epigenetics of epithelial-mesenchymal plasticity in cancer

During the course of malignant cancer progression, neoplastic cells undergo dynamic and reversible transitions between multiple phenotypic states, the extremes of which are defined by the expression