Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.

  title={Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.},
  author={Dongjun Jeong and Hyeongjoo Kim and Doyeon Kim and Seona Ban and Seunghyun Oh and Sanghee Ji and Dong-Ii Kang and Hyunyong Lee and Tae Sung Ahn and Han Jo Kim and Sang Byung Bae and Moon-Soo Lee and Changjin Kim and Hyog Young Kwon and Moo-Jun Baek},
  journal={Oncology reports},
  volume={39 6},
The protein kinase, membrane‑associated tyrosine/threonine 1 (PKMYT1) is known to inhibit precocious entry into mitosis by phosphorylating CDK1 at Thr14 and Tyr15 residues. However, the functional importance of PKMYT1 in colorectal cancer (CRC) remains unknown. Thus, it is important to elucidate whether PKYMT1 is indispensable in the tumorigenesis of CRC. To investigate the functional importance of PKMYT1 in CRC tumorigenesis, PKMYT1 was knocked down in CRC cell lines such as SW480, SW620… 

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