Protein interactions and ligand binding: from protein subfamilies to functional specificity.

@article{Rausell2010ProteinIA,
  title={Protein interactions and ligand binding: from protein subfamilies to functional specificity.},
  author={Antonio Rausell and David de Juan and Florencio Pazos and Alfonso Valencia},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 5},
  pages={
          1995-2000
        }
}
The divergence accumulated during the evolution of protein families translates into their internal organization as subfamilies, and it is directly reflected in the characteristic patterns of differentially conserved residues. These specifically conserved positions in protein subfamilies are known as "specificity determining positions" (SDPs). Previous studies have limited their analysis to the study of the relationship between these positions and ligand-binding specificity, demonstrating… CONTINUE READING

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