Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.

@article{Tan2002ProteinIO,
  title={Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.},
  author={Jiann-an Tan and Susan H. Hall and Katherine G Hamil and Gail Grossman and Peter Petrusz and Frank S. French},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 19},
  pages={16993-7001}
}
Protein inhibitor of activated STAT1 (PIAS1) functions as a nuclear receptor coregulator and is expressed in several cell types of human testis. However, the mechanism of PIAS1 coregulation is unknown. We report here that PIAS1 has characteristics of a scaffold attachment protein. PIAS1 localized in nuclei in a speckled pattern and bound A-T-rich double-stranded DNA, a function of scaffold attachment proteins in chromatin regions of active transcription. DNA binding was dependent on a 35-amino… CONTINUE READING