Protein inference: a review

  title={Protein inference: a review},
  author={Ting Huang and Jingjing Wang and Weichuan Yu and Zengyou He},
  journal={Briefings in bioinformatics},
  volume={13 5},
Assembling peptides identified from tandem mass spectra into a list of proteins, referred to as protein inference, is a critical step in proteomics research. Due to the existence of degenerate peptides and 'one-hit wonders', it is very difficult to determine which proteins are present in the sample. In this paper, we review existing protein inference methods and classify them according to the source of peptide identifications and the principle of algorithms. It is hoped that the readers will… CONTINUE READING
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