Protein-induced folding of a group I intron in cytochrome b pre-mRNA.

@article{Shaw1995ProteininducedFO,
  title={Protein-induced folding of a group I intron in cytochrome b pre-mRNA.},
  author={Lynn Calvin Shaw and Alfred S Lewin},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 37},
  pages={
          21552-62
        }
}
Some group I introns have been shown to be self-splicing in vitro, but perhaps all require proteins for splicing in vivo. Sequence differences affect the stability of secondary structures and may explain why some group I introns function efficiently without protein cofactors while others require them. The terminal intron of the cytochrome b pre-mRNA from yeast mitochondria needs a nucleus-encoded protein for splicing, even though it splices autocatalytically in high salt in vitro. This system… CONTINUE READING

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