Protein-induced fit: the CRP activator protein changes sequence-specific DNA recognition by the CytR repressor, a highly flexible LacI member.

@article{Pedersen1997ProteininducedFT,
  title={Protein-induced fit: the CRP activator protein changes sequence-specific DNA recognition by the CytR repressor, a highly flexible LacI member.},
  author={H B Pedersen and P. Valentin-Hansen},
  journal={The EMBO journal},
  year={1997},
  volume={16 8},
  pages={2108-18}
}
The CytR repressor and the cAMP receptor protein (CRP) bind cooperatively to several promoters in Escherichia coli to repress transcription initiation. The synergistic binding is mediated by protein-protein interactions between the two regulators. Here, in vitro selection experiments have been used to examine the DNA-binding characteristics of CytR, by itself and when co-binding with cAMP-CRP. We show that the optimal CytR-binding site consists of two octamer repeats, in direct or inverted… CONTINUE READING
16 Citations
16 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Differences and similarities in Nørregaard-Madsen,M, Mygind,B., Pedersen,R., Valentin-Hansen,P. and DNA-binding preferences of MyoD and E2A protein complexes Søgaard-Andersen,L

  • T. K. Blackwell, H. Weintraub
  • 1990
Highly Influential
3 Excerpts

Reaching out: locating E.coli

  • R. J. Eustance, S. A. Bustos, R. F. Schleif
  • Nucleic Acids Res
  • 1994

Transcriptional activation

  • D. M. Crothers, T. A. Steitz
  • 1992
2 Excerpts

Similar Papers

Loading similar papers…