Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms.

@article{Jarosz2010ProteinHA,
  title={Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms.},
  author={Daniel F Jarosz and Mikko Taipale and Susan Lindquist},
  journal={Annual review of genetics},
  year={2010},
  volume={44},
  pages={189-216}
}
Changing a single nucleotide in a genome can have profound consequences under some conditions, but the same change can have no consequences under others. Indeed, organisms can be surprisingly robust to environmental and genetic perturbations. Yet, the mechanisms underlying such robustness are controversial. Moreover, how they might affect evolutionary change remains enigmatic. Here, we review the recently appreciated central role of protein homeostasis in buffering and potentiating genetic… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 71 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 178 references

The Origins of Genome Architecture

  • M. Lynch
  • Sunderland, MA: Sinauer Associates, Inc
  • 2007
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…