Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1.

@article{Srivastava2008ProteinHP,
  title={Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1.},
  author={Shekhar Srivastava and Olga Aleksandrovna Zhdanova and Lie Di and Zhai Li and Mamdouh Nasser Albaqumi and Heike Wulff and Edward Y Skolnik},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 38},
  pages={
          14442-6
        }
}
The calcium activated K(+) channel KCa3.1 plays an important role in T lymphocyte Ca(2+) signaling by helping to maintain a negative membrane potential, which provides an electrochemical gradient to drive Ca(2+) influx. We previously showed that nucleoside diphosphate kinase beta (NDPK-B), a mammalian histidine kinase, is required for KCa3.1 channel activation in human CD4 T lymphocytes. We now show that the mammalian protein histidine phosphatase (PHPT-1) directly binds and inhibits KCa3.1 by… CONTINUE READING

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