Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor.


Reactivation of the p53 pathway by a potential therapeutic antagonist, which inhibits HDM2 and HDMX, is an attractive strategy for drug development in oncology. Developing blockers towards conserved hydrophobic pockets of both HDMs has mainly focused on small synthetic compounds; however, this approach has proved challenging. Here we describe an approach to… (More)
DOI: 10.1038/ncomms4814


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